Most Lethal Diseases – 11 Most Deadliest diseases In History of Mankind

most lethal diseases

Throughout the history of mankind, humanity has seen a huge number of most lethal diseases , with the current criteria, either could be classified as epidemic or pandemic depending on how many people affected. Beyond the rigorous classification of the World Health Organization, this list will consider the notorious diseases that have claimed more lives throughout history. Let’s start and do not worry, most of these diseases are relatively controlled or cured check below most lethal diseases.

Check Out Most Lethal Diseases in The History Of Mankind.


Tetanus is a bacterial infection that affects the nervous system and causes strong contractions in muscles, mainly the face and neck, speech, chewing and breathing difficult. Currently, in most countries, it is controlled by the tetanus vaccine.


Leprosy is an infectious disease caused by a bacillus, Mycobacterium leprae. It generates serious ulcers and skin lacerations. It is one of the oldest diseases known active. It is estimated that there for at least 4,000 years. Historically leprosy patients were confined to isolation and lack of treatment. Today there is a cure, although some people still have no access to it.

Bubonic Plague

Bubonic plague is the now extinct disease that emerged in China around 1330, and by 1337 had reached Europe. Between 1338 and 1350 the plague eliminated a quarter of the world population in the fourteenth century, about 25 million people.

Spanish Flu

The Spanish flu epidemic broke out in Europe in 1918 and it is estimated that in just one year more than 1,000 million people were infected. It did not originate in Spain but was given that name because Spain was the only country that was not directly involved in World War II


HIV is the virus that causes AIDS. It is one of the toughest ever discovered virus and causes a disease that today has no cure. Since it was described as a disease, AIDS has ended the lives of about 30 million people.


Plague of Galen

He is also known as Antonina Plague. It took place between the years 165 and 180 AD in Rome. It originated from an infected Roman soldier in the Middle East, returning to Rome spread the disease reached the Emperor Marcus Aurelius.


Malaria is a currently active disease that is transmitted through a mosquito. Its symptoms are similar to Flu. However, it is much more aggressive. It is without doubt one of the most deadly diseases in the world today. Only in 2010, 660,000 people died, mostly in Africa.


In recent months we have had a lot of news about the Ebola since the last outbreak in Guinea. The virus spread rapidly and even reached the United States. The current outbreak is the largest ever recorded Ebola, with more than 2,000 dead. The second outbreak death toll is the 1976 outbreak in Zaire, with only 280 dead


This disease affects the digestive system and has its origin in the consumption of water and food contaminated feces. While no cure, this disease takes between 100,000 and 120,000 lives annually, according to the World Health Organization. Currently is a typical disease of the tropics and especially poor societies with little access to clean water and sanitation.


Tuberculosis is a respiratory disease was the leading cause of death in Latin American cities in the nineteenth and twentieth century. Currently, no cure, although it is not extinct and is positioned as the second most deadly viral disease after HIV. During the year 2012, 1.300.000 people died of tuberculosis.

Yellow Fever

Yellow fever is a disease transmitted by mosquitoes. A huge outbreak occurred in Africa and South America in the late nineteenth century and early twentieth century. Currently, WHO estimates that 200,000 cases occur annually, causing 30,000 deaths, mostly in Africa.